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Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's Disease

Description: PROJECT NARRATIVE This study will measure individual- and environmental-level race-specific stressors and identify the biologic mechanisms linking them to late-life cognitive decline and risk of Alzheimer’s dementia in older Black adults. These data are critical to reduce disparities and the burden of dementia and cognitive decline in a rapidly growing and understudied population.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2004-09-30

End date: 2027-05-31

Investigator: LISA L BARNES

Institution: RUSH UNIVERSITY MEDICAL CENTER

Funded outputs count: 347

Funder award ID: R01AG022018

OpenAlex ID: G9000899922

Digital quantification of vascular β-amyloid and perivascular plaques in cerebral amyloid angiopathy

2026 · Paniz Mojdeganlou, Jennifer Poirier, et al. · Acta Neuropathologica Communications

Associations of longitudinal blood pressure with cerebral amyloid angiopathy in older adults

2026 · Rupal I. Mehta, Ana W. Capuano, et al. · Scientific Reports

Charting Cervical Spinal Cord Morphometry Across the Lifespan

2026 · Kurt G. Schilling, Michael E. Kim, et al. · Human Brain Mapping

Brain DNA methylation, APOE genotype and Alzheimer’s disease neuropathology in a large postmortem cohort

2026 · Guanhong Miao, Cheng Gao, et al. · Nature Aging

Symmetric Centipolar Normalized Score (SCeNS): A standardization framework for fluid marker cross‐comparability in Alzheimer's disease

2026 · Jigyasha Timsina, Yike Chen, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring

Single-nucleus transcriptome-wide association study of human brain disorders

2026 · Sanan Venkatesh, Roman Kosoy, et al. · Nature · 7

Single-nucleus atlas of cell-type specific genetic regulation in the human brain

2026 · Biao Zeng, Hui Yang, et al. · Nature Genetics · 5

AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data

2026 · Chenfeng He, Athan Z. Li, et al. · Nature Medicine · 1

Single-cell atlas of transcriptomic vulnerability across brain disorders

2026 · Donghoon Lee, Mikaela Koutrouli, et al. · Nature · 5

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease

2026 · Pramod Bharadwaj Chandrashekar, Sayali Anil Alatkar, et al. · Nature Communications · 1

Charting confidence in white matter brain charts: enabling study planning through stability validation

2026 · Michael E. Kim, Gaurav Rudravaram, et al. · Journal of medical imaging

Rare extreme polygenic risk scores strongly indicate Alzheimer’s disease risk

2026 · Elizabeth L. Ward, Peter T. Nelson, et al. · medRxiv

The YTHDF proteins modulate Alzheimer’s disease-associated brain gene signatures

2026 · Shinya Tasaki, Denis R. Avey, et al. · Molecular Neurodegeneration

Identification of prevalent dementia in Medicare Advantage encounters, compared with rigorous cohort assessments

2026 · Yi Chen, Slim Benloucif, et al. · The Journals of Gerontology Series A · 1

Altered microglial communication in brains with Alzheimer’s Disease pathology

2026 · Loren dos Santos, Ricardo A. Vialle, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Lasting effects of redlining: The association of historical redlining and cognitive function in older Black adults

2026 · Brittney S. Lange-Maia, Melissa Lamar, et al. · Social Science & Medicine

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery

2026 · Oluwatosin Olayinka, John J. Farrell, et al. · Alzheimer s & Dementia

Arachnoid granulation morphologies and β‐amyloid and tau pathology in older adults

2026 · Rashi I. Mehta, Tianhao Wang, et al. · Alzheimer s & Dementia

The role of vascular risk factors in white matter tract microstructure: a multi‐cohort study in older adults

2026 · James D. LeFevre, Yukti Vyas, et al. · Alzheimer s & Dementia

Cross‐ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts

2026 · Meri Okorie, Caroline Jonson, et al. · Alzheimer s & Dementia · 5

Age at menopause, APOE-ε4, and Alzheimer’s disease risk

2026 · Jennifer Rabin, Madeline Wood Alexander, et al. · Research Square

Associations of Alzheimer Disease and Related Dementia Neuropathologies With Timely Diagnosis of Dementia in Healthcare Settings

2026 · Yi Chen, Annie Chen, et al. · Neurology · 3

Cell-type signatures of Alzheimer’s disease shared across population groups

2026 · Tain Luquez, Jonathan Algoo, et al. · Nature · 4

Time trends in susceptibility to scams in community-dwelling older adults

2026 · Lei Yu, Lianlian Du, et al. · American Journal of Epidemiology

Genetic Associations with Temporal Modeling of Alzheimer’s Disease Progression Supports a Novel Paradigm for Disease Risk

2026 · Daniel M. Jordan, Eli Kritzer, et al. · medRxiv