Platelet Activating Factor and Epidermal Cytoxicity
Description: Short-term ethanol exposure combined with thermal burn injuries results in an acute systemic multi-organ dysfunction as well as delayed immunosuppression. The experiments described in this proposal are designed to test a novel hypothesis that short-term ethanol exposure results in an augmentation of the production of the bioactive lipid mediator Platelet-activating Factor following environmental skin injuries such as thermal burns or ultraviolet B radiation, which can explain the pathological acute and delayed effects of these combined stressors. The information derived from these studies will result in improved understanding and novel therapeutics for patients suffering environmental skin injuries in the setting of ethanol exposure.
Funding type: research
Funder scheme: R01
Start date: 1999-07-01
End date: 2024-11-30
Investigator: JEFFREY B. TRAVERS
Institution: WRIGHT STATE UNIVERSITY
Funded outputs count: 135
Funder award ID: R01HL062996
OpenAlex ID: G405590160