Role of dermal extracellular matrix microenvironment in skin aging
Description: PROJECT NARRATIVE The major goal of this application is to test the novel hypothesis that age-related increased fragmentation of collagen fibrils, due to elevation of matrix metalloproteinase-1 (MMP1), creates an aberrant dermal microenvironment that promotes the aging process and age-related skin pathologies. The proposed studies employ a novel mouse model of accelerated skin aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2016-08-15
End date: 2021-04-30
Investigator: GARY J FISHER
Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 11
Funder award ID: R01AG051849
OpenAlex ID: G8300068219