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Population genomic variation, functional biology, and the risk of venous thrombosis

Description: Narrative The promises of precision medicine leading to healthier lives will be hastened by creating timely, efficient, and effective scientific conduits that rapidly move newly characterized molecular genetic information between genetic epidemiologists and functional biologists. The goals of this project are (a) to coordinate and advance new genetic discovery in the setting of the 2 international consortia on hemostasis and venous thromboembolism; and (b) to integrate the discoveries with functional biology work conducted by laboratory-based research and physician-scientists who develop cell and animal models.
Funding type: research
Funder scheme: R01
Start date: 2017-08-19
End date: 2023-07-31
Investigator: CHARLES J LOWENSTEIN
Institution: UNIVERSITY OF WASHINGTON
Subfield: Hematology
Field: Medicine
Funded outputs count: 43
Funder award ID: R01HL134894
OpenAlex ID: G3249214254
Genomic Evidence Links Inflammation to Residual Pulmonary Vascular Obstruction and Risk of Pulmonary Embolism Recurrence
2026 · Floriane Samaria, Gaelle Munsch, et al. · medRxiv
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Genomic Landscape of Thrombosis Recurrence Risk Across Venous Thromboembolism Subtypes
2024 · Gaëlle Munsch, Florian Thibord, et al. · medRxiv
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Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels
2024 · Julie Hahn, Gerard Temprano-Sagrera, et al. · Journal of Thrombosis and Haemostasis · 3
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Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
2024 · Jennifer E Huffman, Jayna Nicolas, et al. · Blood · 18
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A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
2024 · Paul S. de Vries, Paula Reventun, et al. · Blood · 28
Genetic Determinants of Thrombosis.
2024 · Charles J Lowenstein · PubMed Central · 2
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CD36 regulates factor VIII secretion from liver endothelial cells
2023 · Paula Reventun, Pablo Toledano-Sanz, et al. · Blood Advances · 4
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A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
2023 · Cristina Gallego-Fabrega, Gerard Temprano-Sagrera, et al. · Journal of Thrombosis and Haemostasis · 9
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Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels
2023 · Yuekai Ji, Gerard Temprano-Sagrera, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 8
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Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program
2023 · Amanda A. Seyerle, Cecelia A. Laurie, et al. · Circulation Genomic and Precision Medicine · 12
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DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood
2023 · Julie Hahn, Jan Bressler, et al. · Journal of Thrombosis and Haemostasis · 14
Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platform
2023 · Dre’Von A. Dobson, Lori A. Holle, et al. · Journal of Thrombosis and Haemostasis · 15
The transcriptional landscape of human liver endothelial cells
2023 · Pablo Toledano-Sanz, Paula Reventun, et al. · Blood Advances · 3
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Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
2022 · Florian Thibord, Derek Klarin, et al. · Circulation · 106
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Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies
2022 · Milad Nazarzadeh, Zeinab Bidel, et al. · Cardiovascular Research · 34
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Incident thrombus location and predicting risk of recurrent venous thromboembolism
2022 · Sara C. Lidstrom, Kerri L. Wiggins, et al. · Research and Practice in Thrombosis and Haemostasis · 7
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Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19
2022 · William O. Osburn, Kimberly Smith, et al. · PLoS ONE · 34
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Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors
2022 · Nathan Pankratz, Peng Wei, et al. · Human Molecular Genetics · 18
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
2022 · Gerard Temprano‐Sagrera, Colleen M. Sitlani, et al. · Journal of Thrombosis and Haemostasis · 31
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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
2022 · David Stacey, Lingyan Chen, et al. · Nature Communications · 21
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Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study
2021 · Christina Ellervik, Samia Mora, et al. · Thyroid · 33
Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease
2021 · Richard A. Baylis, Nicholas L. Smith, et al. · Circulation Research · 81
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Comparison of adaptive multiple phenotype association tests using summary statistics in genome-wide association studies
2021 · Colleen M Sitlani, Antoine R Baldassari, et al. · Human Molecular Genetics · 4
Estrogen activates endothelial exocytosis
2021 · Christine S. Kim, Kyungmoo Yea, et al. · Biochemical and Biophysical Research Communications · 13
FGL1 as a modulator of plasma D‐dimer levels: Exome‐wide marker analysis of plasma tPA, PAI‐1, and D‐dimer
2021 · Florian Thibord, Ci Song, et al. · Journal of Thrombosis and Haemostasis · 6
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