Epigenetic gene repression in pulmonary fibrosis
Description: PROJECT NARRATIVE Pulmonary fibrosis is a devastating disease of the lung characterized by progressive accumulation of cells called myofibroblasts which drive the formation of excess connective tissue (scar tissue) leading ultimately to compromised tissue architecture and organ failure. Therapies to halt or reverse this pathological process are limited, making further investigations to understand the mechanisms orchestrating this fatal disease highly relevant. The major pathological feature of lung fibrosis is that it is a chronic process that does not cease, causing perpetuated scar tissue formation, even in the absence of detectable injury and/or inflammation. The reason why the fibrotic process fails to stop is unknown. This proposal will investigate the role of epigenetic modifications, which persistently alter the activation of genes, in the progression of lung fibrosis.
Funding type: research
Funder scheme: R01
Start date: 2018-07-01
End date: 2024-06-30
Investigator: GIOVANNI LIGRESTI
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 29
Funder award ID: R01HL142596
OpenAlex ID: G8674186463