microRNA Regulation of T Cell Senescence
Description: PROJECT NARRATIVE Vaccinations are one of the most successful and safest interventions in modern medicine. However, they have been less beneficial in the older population, in part due to a failure to generate follicular helper T cells supporting the production of protective antibodies as well as a failure to generate long-lived T memory cells. The current proposal aims at identifying regulatory pathways in T cells controlled by microRNAs that contribute to these defects, with the ultimate goal to improve immune memory in older individuals after vaccination.
Funding type: research
Funder scheme: R01
Start date: 2014-01-01
End date: 2025-12-31
Investigator: JORG J GORONZY
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 123
Funder award ID: R01AI108891
OpenAlex ID: G8931658670