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Prospective immune profiling using methylation markers and pancreatic cancer risk

Description: PROJECT NARRATIVE Pancreatic cancer is the fourth leading cause of cancer-related death in the US and is the most rapidly fatal cancer. Early detection is critical for improving prognosis and survival from this disease given that treatment is purely palliative for patients diagnosed late in the progression of the disease. Studies, including ours, suggest that the immune response plays an important role in carcinogenesis; in this proposal, we propose to use DNA methylation markers to identify immune profiles predictive of pancreatic cancer risk.

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2016-08-16

End date: 2020-07-31

Investigator: KARL TIMOTHY KELSEY

Institution: TUFTS UNIVERSITY BOSTON

Funded outputs count: 16

Funder award ID: R01CA207110

OpenAlex ID: G3541414985

Epigenetic ageing during the COVID-19 pandemic: global age acceleration, independent of SARS-CoV-2 infection

2026 · Christopher J. Shore, Marc F. Österdahl, et al. · Clinical Epigenetics

Identification of a foetal epigenetic compartment in adult human kidney

2021 · John K. Wiencke, Ze Zhang, et al. · Epigenetics · 3

DNA methylation ageing clocks and pancreatic cancer risk: pooled analysis of three prospective nested case-control studies

2020 · Mei Chung, Mengyuan Ruan, et al. · Epigenetics · 21

DNA Methylation–Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk

2020 · Dominique S. Michaud, Mengyuan Ruan, et al. · Cancer Epidemiology Biomarkers & Prevention · 14

Epigenome-Wide Association Study Using Prediagnostic Bloods Identifies New Genomic Regions Associated With Pancreatic Cancer Risk

2020 · Dominique S Michaud, Mengyuan Ruan, et al. · JNCI Cancer Spectrum · 17

DNA methylation aging clocks: challenges and recommendations

2019 · Christopher G. Bell, Robert Lowe, et al. · Genome biology · 1,025

SES and correlated factors do not explain the association between periodontal disease, edentulism, and cancer risk

2019 · Jiayun Lu, Ina Zaimi, et al. · Annals of Epidemiology · 6

Absence of an embryonic stem cell DNA methylation signature in human cancer

2019 · Ze Zhang, John K. Wiencke, et al. · BMC Cancer · 6

Variation in DNA methylation of human blood over a 1-year period using the Illumina MethylationEPIC array

2018 · Ina Zaimi, Dong Pei, et al. · Epigenetics · 57

Tracing human stem cell lineage during development using DNA methylation

2018 · Lucas A. Salas, John K. Wiencke, et al. · Genome Research · 42

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

2018 · Lucas A. Salas, Devin C. Koestler, et al. · Genome biology · 419

Immunomethylomics: A Novel Cancer Risk Prediction Tool

2018 · Karl T. Kelsey, John K. Wiencke · Annals of the American Thoracic Society · 16

Maternal serum PFOA concentration and DNA methylation in cord blood: A pilot study

2017 · Samantha L. Kingsley, Karl T. Kelsey, et al. · Environmental Research · 35

Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival

2017 · John K. Wiencke, Devin C. Koestler, et al. · Clinical Epigenetics · 70

A new timepiece: an epigenetic mitotic clock

2016 · Brock C. Christensen, Karl T. Kelsey · Genome biology · 7

Epigenetic Epidemiology as a Tool to Understand the Role of Immunity in Chronic Disease

2016 · Heather H Nelson, Karl T Kelsey · Epigenomics · 8