Functional Analysis Of The Intersection of Mitochondrial Stress and Neurodegeneration
Description: Project Narrative Parkinson Disease (PD) is the most common movement disorder affecting over 1 million Americans, yet underlying causes of this neurodegenerative disease have largely eluded medical science. This proposal is designed to address an unmet challenge of discerning how neurons respond to mitochondrial stress and how this can lead to enhanced susceptibility to neurodegeneration. Understanding the mechanisms underlying this cytotoxicity will be explored using genetics and a whole animal model system whereby outcomes include limiting mitochondrial damage and neurodegeneration in PD.
Funding type: research
Funder scheme: R15
Start date: 2018-09-30
End date: 2022-08-31
Investigator: KIM A CALDWELL (lead)
Institutions: University of Alabama, UNIVERSITY OF ALABAMA IN TUSCALOOSA
Funded outputs count: 8
Funder award ID: R15NS106460
OpenAlex ID: G5198324674