Zfp423 and Progenitor Adipogenesis during Aging
Description: PUBLIC HEALTH RELEVANCE: Adipose senescence during aging leads to metabolic dysfunction and inflammation, but the underlying mechanisms have not been well established. We propose that the impairment in the generation of new adipocytes from progenitor cells is the major reason, and further suggest the involvement of epigenetic changes in such impairment. Our studies will provide molecular target for preventive efforts to prevent adipose senescence, and will likely have applications to the senescence of progenitor cells in other tissues leading to frailty, such as muscle and bones.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2016-09-01
End date: 2019-04-30
Investigator: MIN DU
Institution: WASHINGTON STATE UNIVERSITY
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 24
Funder award ID: R21AG049976
OpenAlex ID: G7001422199