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Diagnostic and prognostic methylation biomarkers for alcohol and related health risks

Description: PROJECT NARRATIVE Alcohol addiction is the third leading lifestyle-related cause of death in the U.S. and is often comorbid with other serious medical conditions such as cardiovascular disease, cirrhosis of the liver and cancer. The goal of this proposal is to develop methylation biomarkers for alcohol addiction and related health risks. Methylation biomarkers can eventually be used to improve the diagnosis, prognosis and treatment of alcohol disorders.
Funding type: research
Funder scheme: R01
Start date: 2017-09-15
End date: 2021-08-31
Investigator: SHAUNNA L CLARK
Institution: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
Field: Medicine
Funded outputs count: 13
Funder award ID: R01AA026057
OpenAlex ID: G1308046133
The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood
2023 · Shaunna L. Clark, Ellen W. McGinnis, et al. · Journal of the American Academy of Child & Adolescent Psychiatry · 9
Methylome-wide association study of anxiety disorders
2023 · John M. Hettema, Edwin J. C. G. van den Oord, et al. · Molecular Psychiatry · 16
A single‐nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens
2022 · Edwin J.C.G. van den Oord, Lin Y Xie, et al. · Addiction Biology · 22
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Dual methylation and hydroxymethylation study of alcohol use disorder
2021 · Shaunna L. Clark, Robin F. Chan, et al. · Addiction Biology · 23
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Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences
2021 · Shaunna L. Clark, Robin Chan, et al. · Journal of the American Academy of Child & Adolescent Psychiatry · 23
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A methylation study of long-term depression risk
2019 · Shaunna L. Clark, Mohammad W. Hattab, et al. · Molecular Psychiatry · 83
A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies
2018 · Shaunna L. Clark, Blair N. Costin, et al. · Alcoholism Clinical and Experimental Research · 11
Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples
2018 · Karolina A. Aberg, Brian Dean, et al. · Molecular Psychiatry · 73
Mapping Risk from Genes to Behavior: The Enduring and Evolving Influence of Irving Gottesman's Endophenotype Concept
2018 · Danielle M. Dick · Twin Research and Human Genetics · 9
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Epigenetic Aging in Major Depressive Disorder
2018 · Laura K.M. Han, Moji Aghajani, et al. · American Journal of Psychiatry · 260
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RaMWAS: fast methylome-wide association study pipeline for enrichment platforms
2018 · Andrey A Shabalin, Mohammad W Hattab, et al. · Bioinformatics · 56
Overestimation of the classification accuracy of a biomarker for assessing heavy alcohol use
2017 · M W Hattab, S L Clark, et al. · Molecular Psychiatry · 15
О дате основания Мегалополя
2007 · Тюряхин Илья Николаевич · Gentiles in late Roman sources
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