Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease
Description: The prevalence of alcohol use disorders and related tissue injuries continues to increase in the United States and contributes to a high mortality and morbidity. The proposed studies will address one of the frequent consequences of alcohol use that is noted in patients with alcoholic liver disease, skeletal muscle loss or sarcopenia. In addition to the potential for development of mechanism based therapies, the proposed studies will also help the applicant become an independent physician scientist in the field of alcoholic liver disease.
Funding type: career_development
Funder scheme: K08
Start date: 2021-03-01
End date: 2027-02-28
Investigator: NICOLE WELCH
Institution: CLEVELAND CLINIC LERNER COM-CWRU
Funded outputs count: 41
Funder award ID: K08AA028794
OpenAlex ID: G9000910774