Mechanistic Basis of Circadian Clocks in Bmal1 Knockout Mice
Description: PROJECT NARRATIVE Circadian clocks have a profound impact on human health as they play a central role in regulating daily physiology, and several studies indicate substantial correlation between circadian dysfunction (e.g. in shift work) and human diseases including cancers, heart disease, lung inflammation, diabetes, metabolic, vascular and mental disorders. This project's goal is to study new types of circadian rhythms in mice that are missing a key molecular component of the core clock machinery – a gene called Bmal1. Gaining new molecular insights into the circadian clockwork will guide future therapeutic interventions to alleviate the disorders associated with circadian disruption, which are highly prevalent in contemporary society.
Funding type: research
Funder scheme: R01
Start date: 2021-05-01
End date: 2025-04-30
Investigator: AKHILESH BASI REDDY
Institution: UNIVERSITY OF PENNSYLVANIA
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 12
Funder award ID: R01GM139211
OpenAlex ID: G8738450073