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Integrative Omics analysis of human cartilage in aging and osteoarthritis

Description: PROJECT NARRATIVE Osteoarthritis affects members of almost every family in the United States. This project will examine gene expression patterns at tissue and single cell levels and regulatory mechanisms that characterize cartilage homeostasis and osteoarthritis in human knees. Data and insight generated from this proposal will provide new and important insights into the pathobiology and osteoarthritis, lead to new biomarkers, and identify more promising targets for therapeutic interventions to prevent or treat osteoarthritis.
Funding type: research
Funder scheme: R01
Start date: 2016-01-15
End date: 2026-05-31
Investigator: MARTIN K LOTZ
Institution: SCRIPPS RESEARCH INSTITUTE, THE
Subfield: Rheumatology
Field: Medicine
Funded outputs count: 41
Funder award ID: R01AG049617
OpenAlex ID: G5346187828
A genetic regulatory map of human synovium and fat pad across the osteoarthritis spectrum
2026 · Yutaro Uchida, Yuta Fujii, et al. · medRxiv
Class I histone deacetylases and their inhibitors as targets to modulate cellular senescence in osteoarthritis
2026 · Kavya Gupta, Hannah Swahn, et al. · GeroScience
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Integrated mapping of human meniscus and cartilage eQTLs reveals shared and distinct osteoarthritis genetic drivers
2026 · Yutaro Uchida, Yuta Fujii, et al. · medRxiv
Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses
2025 · Miguel Otero, Irene Lorenzo Gomez, et al. · Laboratory Investigation · 1
Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium
2025 · Michael D. Newton, Hannah Swahn, et al. · Osteoarthritis and Cartilage · 11
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Histamine H1 receptor inverse agonists improve structure and pain in an osteoarthritis mouse model
2025 · Ichiro Kurakazu, Merissa Olmer, et al. · Journal of Clinical Investigation · 8
Shared and Compartment‐Specific Processes in Nucleus Pulposus and Annulus Fibrosus During Intervertebral Disc Degeneration
2024 · Hannah Swahn, Jasmin Mertens, et al. · Advanced Science · 61
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Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis
2023 · Manabu Kawata, Daniel B. McClatchy, et al. · JCI Insight · 28
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RNA-binding proteins that are highly expressed and enriched in healthy cartilage but suppressed in osteoarthritis
2023 · Hannah Swahn, Merissa Olmer, et al. · Frontiers in Cell and Developmental Biology · 12
Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice
2023 · Shouan Zhu, Huanhuan Liu, et al. · Arthritis & Rheumatology · 16
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Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours
2023 · Alice Courties, Merissa Olmer, et al. · Annals of the Rheumatic Diseases · 18
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Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus
2022 · Hannah Swahn, Kun Li, et al. · Annals of the Rheumatic Diseases · 128
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Transcriptomic analyses of joint tissues during osteoarthritis development in a rat model reveal dysregulated mechanotransduction and extracellular matrix pathways
2022 · Y. Hu, K. Li, et al. · Osteoarthritis and Cartilage · 31
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Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis
2022 · Hiroki Ohzono, Yiwen Hu, et al. · Annals of the Rheumatic Diseases · 81
Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis
2022 · Manabu Kawata, Takeshi Teramura, et al. · Annals of the Rheumatic Diseases · 47
Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
2021 · Yoshiaki Ito, Tokio Matsuzaki, et al. · Nature Communications · 90
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Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity
2020 · Kwang Il Lee, Ramya Gamini, et al. · Science Translational Medicine · 49
Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis
2020 · H. Bekki, T. Duffy, et al. · Osteoarthritis and Cartilage · 46
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Genome‐Wide Occupancy Profiling Reveals Critical Roles of FoxO1 in Regulating Extracellular Matrix and Circadian Rhythm Genes in Human Chondrocytes
2020 · Tomas Duffy, Hirofumi Bekki, et al. · Arthritis & Rheumatology · 29
FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis
2020 · Kwang Il Lee, Sungwook Choi, et al. · Proceedings of the National Academy of Sciences · 83
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Faculty Opinions recommendation of Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage.
2019 · David Young · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis
2018 · K.M. Fisch, R. Gamini, et al. · Osteoarthritis and Cartilage · 273
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
2018 · Oscar Alvarez‐Garcia, Tokio Matsuzaki, et al. · Aging Cell · 89
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Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears
2018 · Kwang Il Lee, Merissa Olmer, et al. · Acta Biomaterialia · 63
Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX 9 and Aggrecan
2018 · Ramon L. Serrano, Liang‐Yu Chen, et al. · Arthritis & Rheumatology · 28
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