T Lymphopenia in Ischemic Heart Failure
Description: PROJECT NARRATIVE Over one million Americans each year are diagnosed with myocardial infarction (MI), of which around 25% will continue to remodel and develop chronic heart failure. The goals of this proposal are to elucidate the molecular mechanisms that cause post-MI T lymphopenia (a decrease in peripheral blood T-cell count) and to investigate whether preventing CD4+ T lymphopenia can serve as a therapeutic strategy. Accomplishment of this proposal will likely provide a potential intervention strategy to improve cardiac repair in ischemic heart failure.
Funding type: research
Funder scheme: R01
Start date: 2022-07-01
End date: 2027-06-30
Investigator: YONGGANG MA
Institution: UNIVERSITY OF SOUTH FLORIDA
Funded outputs count: 6
Funder award ID: R01HL164446
OpenAlex ID: G9000919141