Award

Abeta Toxicity, ROS and Mitochondrial Dysfunction in Aging/Alzheimer's Disease

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2007-07-01

End date: 2012-06-30

Investigator: P. HEMACHANDRA REDDY

Institution: OREGON HEALTH & SCIENCE UNIVERSITY

Funded outputs count: 43

Funder award ID: R01AG028072

OpenAlex ID: G6563441761

Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for Diseases with Oxidative Stress and Mitochondrial Dysfunction

2014 · P. Hemachandra Reddy · Journal of Alzheimer s Disease · 137

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission

2014 · P. Hemachandra Reddy · Drug Discovery Today · 105

Reduced VDAC1 Protects Against Alzheimer's Disease, Mitochondria, and Synaptic Deficiencies

2013 · Maria Manczak, Tatiana Sheiko, et al. · Journal of Alzheimer s Disease · 71

RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity

2013 · Maria Manczak, P. Hemachandra Reddy · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 41

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MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

2013 · Peizhong Mao, Maria Manczak, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 118

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

2013 · P. Hemachandra Reddy · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 147

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Abnormal Interaction of Oligomeric Amyloid-β with Phosphorylated Tau: Implications to Synaptic Dysfunction and Neuronal Damage

2013 · Maria Manczak, P. Hemachandra Reddy · Journal of Alzheimer s Disease · 88

Neurotransmitter CART as a New Therapeutic Candidate for Parkinson’s Disease

2013 · Peizhong Mao, Charles Meshul, et al. · Pharmaceuticals · 23

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Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer’s Disease

2012 · Marcus Calkins, Maria Manczak, et al. · Pharmaceuticals · 73

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Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

2012 · P. Hemachandra Reddy · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 87

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Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

2012 · M. Manczak, P. H. Reddy · Human Molecular Genetics · 348

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Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

2012 · Yusuke Kageyama, Zhongyan Zhang, et al. · The Journal of Cell Biology · 256

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

2012 · P. Mao, M. Manczak, et al. · Human Molecular Genetics · 174

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Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

2012 · M. Manczak, P. H. Reddy · Human Molecular Genetics · 456

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2012 · Maria Manczak, Hiromi Sesaki, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 69

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CART Peptide Is a Potential Endogenous Antioxidant and Preferentially Localized in Mitochondria

2012 · Peizhong Mao, Charles K. Meshul, et al. · PLoS ONE · 56

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Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

2011 · P. Hemachandra Reddy, Ulziibat P. Shirendeb · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 188

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Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging

2011 · Peizhong Mao, Patience Gallagher, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 25

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Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

2011 · P. Hemachandra Reddy, Raghav Tripathi, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 394

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Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

2011 · U. P. Shirendeb, M. J. Calkins, et al. · Human Molecular Genetics · 384

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Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

2011 · M. J. Calkins, M. Manczak, et al. · Human Molecular Genetics · 643

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Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

2011 · Peizhong Mao, P. Hemachandra Reddy · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 314

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Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

2011 · P. Hemachandra Reddy · Brain Research · 304

A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics

2011 · Ulises M. Ricoy, Peizhong Mao, et al. · Neuroscience Letters · 5

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

2011 · P. H. Reddy, T. P. Reddy · Current Alzheimer Research · 227