Next-generation extracellular vesicle biologics to target central nervous system and peripheral reservoirs of HIV
Description: Narrative While antiretroviral therapies are largely effectively at suppressing HIV replication, people living with HIV still experience higher than expected rates of health problems ranging from heart disease to neurocognitive disorders. Redoubled efforts are needed to achieve better long-term control of HIV, including therapies that are highly specific to cells that may be infected with HIV. Extracellular vesicles are small pieces of cells that, much like retroviruses, can transmit proteins, lipids, and other factors between cells in a cell-specific fashion; in this project, we will investigate a validated extracellular vesicle delivery system in a well established animal model of HIV infection and disease. !
Funding type: research
Funder scheme: R01
Start date: 2019-03-05
End date: 2025-02-28
Investigator: BHARAT RAMRATNAM
Institution: JOHNS HOPKINS UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 65
Funder award ID: R01AI144997
OpenAlex ID: G8591866009