Age-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasis
Description: Project Narrative SKN-1/NRF2 plays established roles in xenobiotic responses. As such, the degree of SKN-1/NRF2 activation can impact organism survival during exposure to environmental and endogenous sources of stress. Our published and newly acquired unpublished preliminary data reveals the activation of SKN-1 in worms and NRF2 in mice and humans leads to metabolic dysfunction. Making use of our established C. elegans genetic systems this project will define a new platform for thinking about cytoprotection responses, which will inform strategies to capitalize on the health promoting benefits of molecules like SKN-1 and NRF2 while avoiding pleiotropic outcomes.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2019-08-15
End date: 2025-04-30
Investigator: SEAN P CURRAN
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 34
Funder award ID: R01AG058610
OpenAlex ID: G6315791952