Targeting Mitochondrial Cyclophilin D in Vascular Oxidative Stress and Hypertension
Description: Project Narrative Clinical data show that one third of adult population has hypertension; however, despite treatment with multiple drugs, third of hypertensive patients remain hypertensive which can be potentially corrected with new classes of antihypertensive agents. We have discovered a novel mechanism mitochondrial dysfunction mediated by Cyclophilin D hyperacetylation in human subjects with essential hypertension and developed new mitochondria- targeted drugs to reduce blood pressure and mitigate the end-organ-damage in hypertension. In the proposed studies, we will take this work forward by defining the cell-specific role of vascular cyclophilin D and establish the therapeutic potential of targeting Cyclophilin D in vascular dysfunction and hypertension using novel animal models and vascular tissue from subjects with essential hypertension.
Funding type: research
Funder scheme: R01
Start date: 2019-08-01
End date: 2024-05-31
Investigator: SERGEY DIKALOV (lead)
Institution: Vanderbilt University Medical Center
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 42
Funder award ID: R01HL144943
OpenAlex ID: G1365060714