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Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's disease

Description: NARRATIVE This longitudinal study proposes the use of advanced neuroimaging techniques, including tau and amyloid PET imaging, to detect and track brain changes associated with preclinical Alzheimer’s disease (AD) in a unique kindred with autosomal dominant AD, the largest in the world. This effort will significantly improve our understanding of the evolution of AD pathology, temporal relationships between amyloid pathology, tau pathology and cognitive decline, and will help inform AD prevention trials, including the Alzheimer’s Prevention Initiative autosomal-dominant trial.
Funding type: research
Funder scheme: R01
Start date: 2017-09-01
End date: 2023-12-31
Investigator: YAKEEL T. QUIROZ
Institution: MASSACHUSETTS GENERAL HOSPITAL
Field: Medicine
Funded outputs count: 68
Funder award ID: R01AG054671
OpenAlex ID: G7331518869
Brain metabolic resilience conferred by the APOE3 Christchurch variant in autosomal dominant Alzheimer’s disease and across the adult lifespan
2026 · Yakeel Quiroz, Catarina Tristão-Pereira, et al. · Research Square
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Associations among mild behavioral impairment, cognition, and brain pathology in preclinical autosomal dominant Alzheimer's disease
2026 · Catarina Tristão‐Pereira, Daniel Vasquez, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Longevity and cognitive resilience in a Colombian family carrying the APOE ε2 variant
2026 · Alejandro Guerrero, Nelson David Galvis-Garrido, et al. · Journal of Alzheimer s Disease · 1
Vulnerability of the locus coeruleus–entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease
2026 · Elouise A. Koops, Averi Giudicessi, et al. · Alzheimer s & Dementia
Long‐term forgetting, sleep, and tau in autosomal‐dominant Alzheimer's disease
2026 · Jason C. You, Alex C. Bender, et al. · Alzheimer s & Dementia · 1
Sex differences in diffusion-weighted imaging outcomes in autosomal dominant Alzheimer’s disease
2026 · Averi Giudicessi, Elouise Koops, et al. · Brain Communications
Association among cardiorespiratory fitness, plasma biomarkers of pathology and astrocyte reactivity, and cognition in autosomal-dominant Alzheimer's disease
2025 · Edmarie Guzmán-Vélez, David Aguillón, et al. · Journal of Alzheimer s Disease · 2
Protective genetic variants against Alzheimer's disease
2025 · Claudia Marino, Vincent Malotaux, et al. · The Lancet Neurology · 20
Religious stress coping is associated with lower entorhinal tau pathology and better memory performance in autosomal dominant Alzheimer's disease
2025 · Jairo E Martinez, Yamile Bocanegra, et al. · Journal of Alzheimer s Disease
Risk Factors for Poor Sleep Quality and Subjective Cognitive Decline in Older Adults Living in the United States During the COVID-19 Pandemic
2025 · Celina Pluim McDowell, Jairo E. Martinez, et al. · Healthcare · 3
Connectome‐based predictive modeling of brain pathology and cognition in autosomal dominant Alzheimer's disease
2025 · Vaibhav Tripathi, Joshua Fox‐Fuller, et al. · Alzheimer s & Dementia · 8
Heparin treatment is associated with a delayed diagnosis of Alzheimer’s dementia in electronic health records from two large United States health systems
2024 · Benjamin Readhead, Eyal Klang, et al. · Molecular Psychiatry · 8
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Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer’s disease
2024 · Stephanie Langella, Kyra Bonta, et al. · Alzheimer s Research & Therapy · 9
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Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal‐dominant Alzheimer's disease
2024 · Edmarie Guzmán‐Vélez, Angelys Rivera‐Hernández, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions
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Physical Activity and Neurocognitive Symptoms in Older Adults During COVID-19 Pandemic
2024 · Perla K. Ortiz-Acosta, Jairo E. Martínez, et al. · Journal of Applied Gerontology
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Cognitive Outcomes in Autosomal-Dominant Alzheimer’s Disease: A Comprehensive Review from a Colombian Kindred with the Presenilin-1 E280A Mutation
2024 · Averi Giudicessi, Celina Pluim McDowell, et al. · Journal of Alzheimer s Disease · 7
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Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults
2024 · Catherine E. Munro, Michelle Farrell, et al. · JAMA Network Open · 17
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Primary lateral sclerosis associated with PSEN1 Pro284Leu variant in a Colombian family: Clinical and neuropathological features
2024 · Juliana Acosta‐Uribe, Andrés Villegas‐Lanau, et al. · Alzheimer s & Dementia · 4
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
2024 · Courtney M. Kloske, Michael E. Belloy, et al. · Alzheimer s & Dementia · 33
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APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease
2024 · Yakeel T. Quiroz, David Aguillon, et al. · New England Journal of Medicine · 63
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APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases
2024 · Paula Perez-Corredor, Timothy E. Vanderleest, et al. · Frontiers in Molecular Neuroscience · 28
The MAPP Room Memory Test: Examining Contextual Memory Using a Novel Computerized Test in Cognitively-Unimpaired Individuals with Autosomal Dominant Alzheimer's Disease
2024 · A. Giudicessi, P.A. Aduen, et al. · The Journal of Prevention of Alzheimer s Disease · 5
Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease
2023 · Stephanie Langella, Francisco Lopera, et al. · Alzheimer s & Dementia · 12
APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation
2023 · Claudia Marino, Paula Perez‐Corredor, et al. · Alzheimer s & Dementia · 45
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Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer’s disease
2023 · Stephanie Langella, N. Gil Barksdale, et al. · Nature Communications · 30
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