Award

Role of FoxOs in Skeletal Homeostasis- Resubmission

Description: PUBLIC HEALTH RELEVANCE: Osteoporosis is one of the most common features of human aging, but the mechanisms responsible for this condition remain unclear. As it is unclear whether these mechanisms are specific for bone or are shared by other tissues and organs. The work proposed in this application seek to identify the means by which aging causes bone loss by studying changes in the function of proteins that control both the bone-resorbing cells and the bone-forming cells. Increase understanding of the mechanisms that control bone cells may prove useful for the development of therapies that can treat osteoporosis and other degenerative disorders of aging.

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding type: research

Funder scheme: R01

Start date: 2008-12-01

End date: 2022-01-31

Investigator: MARIA JOSE ALMEIDA

Institution: UNIV OF ARKANSAS FOR MED SCIS

Topic: FOXO transcription factor regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 52

Funder award ID: R01AR056679

OpenAlex ID: G7813502248