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SPORE in Ovarian Cancer

Description: The outcomes to be delivered from the Johns Hopkins – University of Pennsylvania Ovarian SPORE will generate new information to prevent, diagnose, and treat ovarian cancer patients more effectively. Our results should have significant public health relevance.
Funding type: program
Funder scheme: P50
Start date: 2018-09-18
End date: 2029-07-31
Investigator: RONNY I DRAPKIN
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 139
Funder award ID: P50CA228991
OpenAlex ID: G9000885337
Targeting Tumor Immunity: Statins as a Repurposed Strategy for Preventing Ovarian Cancer Advancement
2026 · Juliane M. Liberto, Sumeng Qi, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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PTEN deficiency confers sensitivity to ATR inhibitor–based treatment in high-grade serous ovarian cancer
2026 · Jie Hao, Bose Kochupurakkal, et al. · Journal of Clinical Investigation
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Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development
2026 · André Forjaz, Marco Costa, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Tumor‐Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance
2026 · Allison Jorgensen, Daniel W. Vermeer, et al. · Advanced Biology · 2
Integrated Spatial Analysis Reveals the Molecular Landscape of Ovarian Precancerous Lesions
2025 · Tu-Yung Chang, Yen-Wei Chien, et al. · Cancer Research · 7
Inverse correlation between Lamin A/C and survival in ovarian cancer: implications for predicting responsiveness to taxane-based chemotherapy
2025 · Elizabeth R. Smith, Isaac R.L. Xu, et al. · Gynecologic Oncology Reports
Macrophages and neutrophils in ovarian cancer microenvironment
2025 · Kuang-Chao Cheng, Yu-Hsin Lin, et al. · Frontiers in Immunology · 11
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Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer
2025 · Chunlei Shao, Alexandra Indeglia, et al. · Genes & Development · 4
Genomic Landscapes of Endometrioid and Mucinous Ovarian Cancers and Morphologically Similar Tumor Types
2025 · Dorothy Hallberg, Alice C. Eastman, et al. · Cancer Research Communications · 2
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Modulating Glutamine Metabolism Reprograms Pro-Inflammatory Differentiation in Macrophages
2025 · Sumeng Qi, Jiawei Fan, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability
2025 · Tae-Hee Lee, Colina X. Qiao, et al. · Nature Communications · 4
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Selective Alanine Transporter Utilization Is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer
2025 · Hao Nie, Liping Liao, et al. · Cancer Research · 4
Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment
2025 · Tianhe Li, Sepehr Akhtarkhavari, et al. · Advanced Biology · 8
Integrated Spatial Analysis of Ovarian Precancerous Lesions
2025 · Tu-Yung Chang, Yen-Wei Chien, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Evaluating a patient ambassador program to improve clinical trial knowledge and intent to discuss gynecologic oncology trials
2025 · Emily M. Ko, Christine Pae, et al. · Gynecologic Oncology
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Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR
2025 · Haineng Xu, Erin George, et al. · Nature Communications · 34
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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube
2025 · Ian Beddows, Svetlana Djirackor, et al. · Nature Communications · 6
Serous tubal intraepithelial carcinoma—looking into the earliest events of ovarian cancer development
2025 · Ie-Ming Shih, Yeh Wang, et al. · Academia oncology. · 3
Cancer Antigen 125 Levels at Time of Ovarian Cancer Diagnosis by Race and Ethnicity
2025 · Anna Jo Bodurtha Smith, Emily Gleason, et al. · JAMA Network Open · 11
Aged and BRCA -Mutated Stromal Cells Drive Epithelial Cell Transformation
2025 · Geyon L. Garcia, Taylor Orellana, et al. · Cancer Discovery · 11
APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition
2025 · Jessica M. Devenport, Thi Tran, et al. · JCI Insight · 7
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LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker
2025 · Pamela R. de Santiago, Sho Sato, et al. · npj Precision Oncology · 8
ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer
2025 · Lora Stojanovic, Rachel Abbotts, et al. · Cancer Research · 14
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
2024 · Tanjina Kader, Jia-Ren Lin, et al. · Cancer Discovery · 59
Telehealth in Gynecologic Oncology Clinical Trials
2024 · Leslie Andriani, Linda M. Saikali, et al. · O&G Open · 1
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