Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.
Description: Project Narrative We have discovered a novel mechanism by which aggressive breast cancer cells give rise to a secretome consisting of exosomes with unique protein cargo and soluble cathepsins that stimulates the migration and invasive activity of cells, and thus increases their potential for metastatic spread. This mechanism involves the coordination between the down-regulation of the NAD+-dependent deacetylase Sirtuin 1 (SIRT1) and the glutamine addiction characteristic of breast cancer cells. In the proposed studies, we will determine how these changes in SIRT1 expression/activity and cancer cell metabolism work together to drive metastatic spread with the over-riding goal of identifying new potential strategies to intervene against breast cancer metastasis.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2022-02-01
End date: 2027-01-31
Investigator: MARC A ANTONYAK
Institution: CORNELL UNIVERSITY
Funded outputs count: 22
Funder award ID: R01CA259195
OpenAlex ID: G9000873290