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Induction of fat regeneration in skin wounds by hair follicle signaling

Description: PUBLIC HEALTH RELEVANCE: Skin quickly loses its embryonic regeneration potential, and wound healing in adult skin yields fibrous scars. Adipose tissue, a normal component of the skin, is distinctly missing from cutaneous scars. This application will explore the previously unknown mechanism that enables adult skin to regenerate functional adipose tissue during wound healing, thereby opening new therapeutic possibilities for embryonic-like, scarless regeneration.

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding type: research

Funder scheme: R01

Start date: 2014-09-18

End date: 2020-08-31

Investigator: MAKSIM V PLIKUS

Institution: UNIVERSITY OF CALIFORNIA-IRVINE

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 40

Funder award ID: R01AR067273

OpenAlex ID: G8617421475