Role of Prokineticin 2 in Metal Neurotoxicity
Description: Narrative Chronic environmental exposure to the heavy metal manganese (Mn) through occupational and industrial sources causes motor and not-motor neurological deficits, culminating in metal-induced Parkinsonism. Even though it is well known that Mn neurotoxicity primarily affects the globus pallidus and striatum regions, the molecular mechanisms underlying the metal-induced differential neuronal vulnerability and olfactory alterations are not well understood. In this proposal, we intend to characterize the role of a compensatory signaling pathway mediated by the neuropeptide prokineticin 2 in Mn-induced olfactory alterations and basal ganglia neurotoxicity and to further evaluate the translational neuroprotective efficacy of activating this signaling pathway using both cell and animal models of Mn neurotoxicity.
Funding type: research
Funder scheme: R01
Start date: 2023-01-25
End date: 2027-10-31
Investigator: ANUMANTHA GOUNDER KANTHASAMY
Institution: UNIVERSITY OF GEORGIA
Funded outputs count: 8
Funder award ID: R01ES034196
OpenAlex ID: G9000901425