Protection of stressed hematopoietic stem cells by the tetraspanin family member CD53
Description: Project Narrative Inflammation can impair normal hematopoietic stem cell (HSC) function, and can promote the clonal expansion of mutant HSCs. We have identified the tetraspanin family member CD53 as a critical regulator of HSC function in the context of inflammatory stress, and propose to identify the mechanisms by which CD53 regulates both normal and mutant HSCs.
Funding type: research
Funder scheme: R01
Start date: 2017-01-01
End date: 2026-12-31
Investigator: LAURA G. SCHUETTPELZ
Institution: WASHINGTON UNIVERSITY
Funded outputs count: 13
Funder award ID: R01HL134896
OpenAlex ID: G9000863684