Award

Role of Mitochondrial Homeostasis in Animal Aging

Description: Project Narrative Advanced age is the greatest risk factor for the onset and progression of Alzheimer's disease. We are using the powerful genetics of the fruit fly Drosophila to better understand the biological mechanisms of aging. The long-term goal of this research is to provide novel therapeutic targets to counteract age-related human diseases, including Alzheimer's disease.
Funding type: research
Funder scheme: R01
Start date: 2010-07-01
End date: 2027-12-31
Investigator: DAVID W WALKER (lead)
Institutions: University of California, Los Angeles, UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 32
Funder award ID: R01AG037514
OpenAlex ID: G9000904008
2025 · Larisa Sarghie, Paula Istvan, et al. · Frontiers in Microbiology
2024 · Edward T. Schmid, Joseph M. Schinaman, et al. · Nature Communications · 37
2023 · Mudra Choudhury, Ting Fu, et al. · Science Advances · 28
2023 · Anna M. Salazar, Ricardo Aparicio, et al. · Disease Models & Mechanisms · 104
2022 · Edward T. Schmid, Jung-Hoon Pyo, et al. · Nature Aging · 75
2022 · Ricardo Aparicio, Edward T. Schmid, et al. · Nature Aging · 5
2021 · Misa Belser, David W. Walker · Frontiers in Genetics · 26
2019 · Joseph M. Schinaman, Anil Rana, et al. · Scientific Reports · 101
2018 · Anna M. Salazar, Martin Resnik-Docampo, et al. · iScience · 58
2018 · Malene Hansen, David C. Rubinsztein, et al. · Nature Reviews Molecular Cell Biology · 802
2017 · Rebecca I. Clark, David W. Walker · Cellular and Molecular Life Sciences · 118
2017 · Anil Rana, Matheus P. Oliveira, et al. · Nature Communications · 304
2016 · Christopher L. Koehler · eScholarship (California Digital Library)
2015 · Amalia Icreverzi, Aida Flor A. de la Cruz, et al. · Aging Cell · 13
2014 · Matthew Ulgherait, Anil Rana, et al. · Cell Reports · 316
2014 · Jae H. Hur, Devon A. Stork, et al. · Journal of Bioenergetics and Biomembranes · 27
2013 · Ana Maria Cuervo, Susmita Kaushik · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
2013 · Rebecca I. Clark, Sharon W.S. Tan, et al. · Cell · 169