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The importance of mTOR signaling in cardiac aging and lifespan in mammals

Description: PUBLIC HEALTH RELEVANCE: These genetic approaches will lead to fundamental insights into key regulators of longevity and determinants of health span, and that with this knowledge, pharmacologic interventions can be designed to confer similar health benefits to humans. Cardiac aging is a significant cause of late-life mortality and diastolic dysfunction is a major contributor to the physiological declines In the aging heart. The proposed studies may reveal novel therapeutic interventions for diastolic dysfunction which currently are sorely lacking.
Funding type: research
Funder scheme: R01
Start date: 2010-07-01
End date: 2016-06-30
Investigator: PETER S RABINOVITCH
Institution: UNIVERSITY OF WASHINGTON
Subfield: Aging
Funded outputs count: 16
Funder award ID: R01AG038550
OpenAlex ID: G8853972315
Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
2019 · Ellen Quarles, Nathan Basisty, et al. · Aging Cell · 103
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Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure
2019 · Dao-Fu Dai, Yonggang Liu, et al. · GeroScience · 17
Rapamycin Treatment Promotes Myofibril Relaxation Kinetics and Reduces Myocardial Stiffness to Improve Diastolic Function in Old Murine Hearts
2018 · Ying Ann Chiao, Farid Moussavi‐Harami, et al. · The FASEB Journal
Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
2017 · Matthew J. Yousefzadeh, Marissa J. Schafer, et al. · Aging Cell · 114
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Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment
2017 · Nathan B Basisty, Yuxin Liu, et al. · The Journals of Gerontology Series A · 24
Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts
2016 · Ying Ann Chiao, Stephen C. Kolwicz, et al. · Aging · 128
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The Aging Heart: Figure 1.
2015 · Ying Ann Chiao, Peter S. Rabinovitch · Cold Spring Harbor Perspectives in Medicine · 200
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Mitochondrial dysfunction in cardiac aging
2015 · Autumn Tocchi, Ellen K. Quarles, et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 152
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Interstitial pericytes decrease in aged mouse kidneys
2015 · Ania Stefanska, Diana Eng, et al. · Aging · 45
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Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age
2015 · Sebastian S. Roeder, Ania Stefanska, et al. · American Journal of Physiology-Renal Physiology · 62
Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments
2015 · Pabalu P. Karunadharma, Nathan Basisty, et al. · The FASEB Journal · 69
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects
2015 · Pabalu P. Karunadharma, Nathan Basisty, et al. · Aging Cell · 79
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Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart
2014 · Dao‐Fu Dai, Pabalu P. Karunadharma, et al. · Aging Cell · 328
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mTOR is a key modulator of ageing and age-related disease
2013 · Simon C. Johnson, Peter S. Rabinovitch, et al. · Nature · 1,676
Topograph, a Software Platform for Precursor Enrichment Corrected Global Protein Turnover Measurements
2012 · Edward J. Hsieh, Nicholas J. Shulman, et al. · Molecular & Cellular Proteomics · 57
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Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival
2012 · Fresnida J. Ramos, Steven C. Chen, et al. · Science Translational Medicine · 349
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