Fibrogenic activation and memory in the lung mesenchyme
Description: Project Narrative Interstitial lung diseases (ILDs) including idiopathic and other forms of pulmonary fibrosis are a major and growing medical burden. Fibrosis progression in these diseases is driven by the persistent activation of fibroblasts; understanding how fibroblasts become activated and then locked in fibrogenic states is central to the development more effective therapies for fibrotic ILDs. The proposed studies will test the role and regulation of the transcription factor Runx1 in fibrogenic cell activation and memory in mouse models and human tissue, potentially identifying a novel targetable mechanism underlying fibrotic ILD progression.
Funding type: research
Funder scheme: R01
Start date: 2022-12-01
End date: 2026-11-30
Investigator: DANIEL J. TSCHUMPERLIN
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 10
Funder award ID: R01HL166187
OpenAlex ID: G9000886585