Transcriptional Control of Neuroinflammation in Alzheimer's Disease
Description: PROJECT NARRATIVE Proinflammatory Th17 and microglial cells have been implicated in Alzheimer’s disease (AD). However, the understanding of their roles in neuroinflammation that drive the AD pathogenesis is limited. In this study we will investigate the mechanisms underlying the regulation of peripheral Th17 and central microglial cells in AD development and progression, as well as the therapeutic potential of pharmacological inhibition of the production of proinflammatory Th17 and microglial cytokines as new immunomodulation therapy for AD.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2021-06-15
End date: 2027-02-28
Investigator: DONGMING CAI
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 28
Funder award ID: R01AG072562
OpenAlex ID: G9000887338