First Comprehensive Mitochondrial DNA Brain Mutation Atlas for Alzheimer's Disease
Description: NARRATIVE The purpose of this research proposal is to develop a comprehensive Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) brain atlas of acquired mitochondrial DNA (mtDNA) mutations (heteroplasmy) across multiple brain regions and in blood from autopsy samples collected from the 50+ year Kuakini Honolulu Heart Program/Kuakini Honolulu-Asia Aging Study (Kuakini HHP/Kuakini HAAS) cohort of American men of Japanese ancestry. Identifying brain and blood heteroplasmy across six brain regions and blood in a longitudinal cohort will advance the discovery of disease mechanisms related to early AD/ADRD diagnosis, neuropathology, and cognitive decline. The work performed by this study team comprised of experts in mtDNA sequencing, AD/ADRD diagnosis and assessment, neuropathology, cognitive aging, biostatistics and risk-factor modeling, will fill a major gap in the understating of brain and blood mtDNA heteroplasmy in AD/ADRD etiology, neuropathology, and risk of cognitive decline.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2005-09-30
End date: 2030-05-31
Investigator: GREGORY J. TRANAH
Institution: KUAKINI MEDICAL CENTER
Funded outputs count: 79
Funder award ID: R01AG027060
OpenAlex ID: G9000908660