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The Role of TGF-beta Activation and Signaling in Aortic Stenosis Progression

Description: PROJECT NARRATIVE Aortic stenosis (AS) affects many elderly Americans and is an independent risk factor for heart failure, the leading cause of death in the U.S. Currently, the only treatment for AS is invasive and risky valve replacement. The proposed research seeks to better understand the mechanisms of AS progression and to develop urgently needed new diagnostic, prognostic, and therapeutic approaches for AS.
Funding type: research
Funder scheme: R01
Start date: 2020-04-01
End date: 2025-02-28
Investigator: JASIMUDDIN AHAMED
Institution: OKLAHOMA MEDICAL RESEARCH FOUNDATION
Field: Medicine
Funded outputs count: 20
Funder award ID: R01HL148123
OpenAlex ID: G6362793718
Atorvastatin suppresses HIV/antiretroviral drug–induced cardiac fibrosis and dysfunction in mice by blocking platelet TGF-β1 signaling
2026 · Kumar Subramani, Denys Babii, et al. · JCI Insight · 2
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Binding requirements for latent transforming growth factor Beta2 activation
2024 · Nalani Sachan, Colin K.L. Phoon, et al. · Matrix Biology Plus
Evidence That Anemia Accelerates AS Progression Via Shear-Induced TGF-β1 Activation
2023 · Kumar Subramani, Jeffrey Bander, et al. · JACC Basic to Translational Science · 8
PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves
2023 · Yen-Chun Ho, Xin Geng, et al. · Circulation Research · 18
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Defibrotide mitigates endothelial cell injury induced by plasmas from patients with COVID-19 and related vasculopathies
2023 · Sonia Elhadad, David Redmond, et al. · Thrombosis Research · 8
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The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner
2022 · Ping Li, Maria F. Newhardt, et al. · GeroScience · 26
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Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease
2022 · Huiping Shi, Bojing Shao, et al. · Proceedings of the National Academy of Sciences · 26
Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches
2022 · Jasimuddin Ahamed, Jeffrey Laurence · Journal of Clinical Investigation · 122
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C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy
2022 · Sonia Elhadad, Amy Chadburn, et al. · Bone Marrow Transplantation · 14
Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage
2022 · Jeffrey Laurence, Gerard Nuovo, et al. · American Journal Of Pathology · 17
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Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver
2022 · Sandra Gostynska, Thamizhiniyan Venkatesan, et al. · Blood Advances · 17
N-Acetylcysteine Inhibits Aortic Stenosis Progression in a Murine Model by Blocking Shear-Induced Activation of Platelet Latent Transforming Growth Factor Beta 1
2021 · Sandeep Subrahmanian, Rohan Varshney, et al. · Antioxidants and Redox Signaling · 5
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L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus
2021 · Yuji Kondo, Jason L. Larabee, et al. · JCI Insight · 45
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Tissue factor upregulation is associated with SARS‐CoV‐2 in the lungs of COVID‐19 patients
2021 · Sandeep Subrahmanian, Alain Borczuk, et al. · Journal of Thrombosis and Haemostasis · 42
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Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
2020 · Madhav Seshadri, Jasimuddin Ahamed, et al. · Thrombosis Update · 7
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Severe aortic stenosis patient risk during the COVID-19 pandemic
2020 · Jasimuddin Ahamed · Open Heart · 10
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MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab
2020 · S Elhadad, J Chapin, et al. · Clinical & Experimental Immunology · 57
Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator
2019 · Karim Kouzbari, Mohammad R. Hossan, et al. · Scientific Reports · 38
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Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model
2019 · Rohan Varshney, Brennah Murphy, et al. · Blood Advances · 41
HIV Protease Inhibitor Ritonavir Induces Renal Fibrosis and Dysfunction: Role of Platelet-Derived TGF-β1 and Intervention via Anti-Oxidant Pathways
2019 · Jeffrey Laurence, Sonia Elhadad, et al. · AIDS · 13
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