Mechanisms of Malnutrition in Cirrhosis with Portosystemic Shunting
Description: Understanding the mechanisms of muscle loss or sarcopenia in cirrhosis will permit development of novel, effective and targeted therapies. A comprehensive array of animal and in vitro cell culture studies will be used to identify a novel non-canonical activation of and signaling by adapter protein, MyD88 by the ammonia transport protein, RhBG. This upstream response activates both myostatin-AMPK and hypoxia inducible factor 1α that converge and inhibit mTORC1, a critical regulator of protein synthesis in the skeletal muscle with resultant sarcopenia.
Funding type: research
Funder scheme: R01
Start date: 2011-08-20
End date: 2023-05-31
Investigator: SRINIVASAN DASARATHY
Institution: CLEVELAND CLINIC LERNER COM-CWRU
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 98
Funder award ID: R01GM119174
OpenAlex ID: G7043152038