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Elucidating Synaptic Regulators via High-Throughput Morphology Characterization

Description: PUBLIC HEALTH RELEVANCE: Defective neurotransmission is the cause of many neurological diseases ranging from depression to autism. Understanding the regulators of synaptic strength can shed light on pathways that play a role in establishing healthy synaptic function, and treatments for neurotransmission-related diseases.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R00

Start date: 2016-07-01

End date: 2021-04-30

Investigator: ADRIANA SAN MIGUEL

Institution: NORTH CAROLINA STATE UNIVERSITY RALEIGH

Funded outputs count: 12

Funder award ID: R00AG046911

OpenAlex ID: G5948682388

Amyloid β induces hormetic-like effects through major stress pathways in a C. elegans model of Alzheimer’s Disease

2025 · James D. Lichty, Hrishikesh Mane, et al. · PLoS ONE · 4

Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

2023 · Javier Huayta, Joseph P. Crapster, et al. · Communications Biology · 14

Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation

2022 · Daniel F. Midkiff, Javier Huayta, et al. · iScience · 7

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

2021 · Karthik Suresh Arulalan, Javier Huayta, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

2021 · Karthik Suresh Arulalan, Javier Huayta, et al. · Exposome · 3

Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock

2020 · Sahand Saberi-Bosari, Kevin B. Flores, et al. · BMC Biology · 19

An inexpensive programmable optogenetic platform for controlled neuronal activation regimens in C. elegans

2020 · Zachary Crawford, Adriana San-Miguel · APL Bioengineering · 9

Capture of Chinese Hamster Ovary Host Cell Proteins from Therapeutic Monoclonal Antibody Production Harvest by Mixed-Mode Synthetic Ligands.

2019 · Rebecca Ashton Bradley Lavoie · NCSU Libraries Repository (North Carolina State University Libraries)

Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds

2019 · Sahand Saberi-Bosari, Mohammad Omary, et al. · Scientific Reports · 21

A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans

2018 · Sahand Saberi-Bosari, Javier Huayta, et al. · Lab on a Chip · 33

Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

2016 · Adriana San-Miguel, Peri T. Kurshan, et al. · Nature Communications · 39