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Myostatin Alters Muscle Composition as The Result of an ACL Injury

Description: Project Narrative Anterior cruciate ligament reconstructions are a common procedure resulting in significant quadriceps muscle strength loss which is linked to poorer functional outcomes. Increases in myostatin following anterior cruciate ligament injury can impede muscle recovery by promoting alterations in the cellular and morphological composition of the muscle. The goal of this proposal is to determine the time course of deleterious changes within the injured limb muscle and identify myostatin as integral in the etiology of protracted muscle weakness in individuals following an ACL tear and reconstruction.
Funding type: research
Funder scheme: R01
Start date: 2018-03-26
End date: 2025-02-28
Investigator: CHRISTOPHER FRY
Institution: UNIVERSITY OF KENTUCKY
Subfield: Surgery
Field: Medicine
Funded outputs count: 37
Funder award ID: R01AR072061
OpenAlex ID: G817388480
ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice
2026 · Nicholas T. Thomas, Camille R. Brightwell, et al. · Molecular Medicine
Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury
2026 · Alexander R. Keeble, Allison M. Owen, et al. · Function · 1
Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury
2026 · Alexander R. Keeble, Allison M. Owen, et al. · BMC Medicine · 2
Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading
2026 · Alexander R. Keeble, Sara Gonzalez-Velez, et al. · Journal of Applied Physiology · 2
Zinc deficiency contributes to blunted myogenesis in chronic kidney disease
2025 · Alexander R. Keeble, Sara Gonzalez-Velez, et al. · American Journal of Physiology-Cell Physiology
Open-Source AI for Vastus Lateralis and Adipose Tissue Segmentation to Assess Muscle Size and Quality
2025 · McKenzie S. White, Arimitsu Horikawa-Strakovsky, et al. · Ultrasound in Medicine & Biology · 3
Exploring the Influence of Quadriceps Peak Torque and Rate of Torque Development on Running Mechanics After Anterior Cruciate Ligament Reconstruction
2025 · Amit M. Gohil, Gregory S. Hawk, et al. · Sports Health A Multidisciplinary Approach · 3
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Fork in the road: therapeutic and pathological actions for fibro‐adipogenic progenitors following musculoskeletal injury
2025 · Allison M. Owen, Sara Gonzalez‐Velez, et al. · The Journal of Physiology · 4
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CSF1‐R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury
2024 · Alexander R. Keeble, Nicholas T. Thomas, et al. · The Journal of Physiology · 12
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Genetic Predictors of Bone Density Loss After Anterior Cruciate Ligament Reconstruction
2024 · Angelique N Sciascia, Douglas E Long, et al. · Current Developments in Nutrition
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Identification of Phytochemical Formosanin C-induced Ferroptosis in Colorectal Cancer Through Bioinformatics Approaches
2024 · Chun-Li Su, Hsin-Chih Chen, et al. · Current Developments in Nutrition
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Developing an Objective Method to Improve the Causal Estimates of Dietary Traits on Metabolic Health Outcomes in Mendelian Randomization
2024 · Kristen J Sutton, Joanne Cole · Current Developments in Nutrition
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Sex Differences in Quadriceps Atrophy After Anterior Cruciate Ligament Tear
2024 · Meredith K. Owen, Kelsey R. Casadonte, et al. · Sports Health A Multidisciplinary Approach · 12
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Overexpression of manganese superoxide dismutase mitigates ACL injury-induced muscle atrophy, weakness and oxidative damage
2023 · Christine M. Latham, Peyton J. Balawender, et al. · Free Radical Biology and Medicine · 20
GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury
2023 · Camille R. Brightwell, Christine M. Latham, et al. · Science Advances · 27
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Pharmacologic Inhibition of Myostatin With a Myostatin Antibody Improves the Skeletal Muscle and Bone Phenotype of Male Insulin‐Deficient Diabetic Mice
2023 · R Clay Bunn, Reuben Adatorwovor, et al. · JBMR Plus · 9
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Vitamin D status associates with skeletal muscle loss after anterior cruciate ligament reconstruction
2023 · Yuan Wen, Christine M. Latham, et al. · JCI Insight · 12
Relationship Between Quadriceps Strength and Knee Joint Power During Jumping After ACLR
2023 · Megan C. Graham, Kelsey A. Reeves, et al. · Orthopaedic Journal of Sports Medicine · 24
Cutting edge concepts: Does bilirubin enhance exercise performance?
2023 · Kyle D. Flack, Libor Vítek, et al. · Frontiers in Sports and Active Living · 20
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Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear–Resultant Quadriceps Atrophy
2022 · Alexander R. Keeble, Camille R. Brightwell, et al. · The American Journal of Sports Medicine · 22
Vitamin D status associates with skeletal muscle loss after anterior cruciate ligament reconstruction
2022 · Jean L. Fry, Angelique N. Moore, et al. · medRxiv
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A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy
2022 · Camille R. Brightwell, Christine M. Latham, et al. · American Journal of Physiology-Cell Physiology · 52
Anterior Cruciate Ligament Reconstruction Upregulates Vitamin D Activating Pathways within the Quadriceps
2022 · Jean L. Fry, Camille R. Brightwell, et al. · The FASEB Journal
Enhanced Senescent Cell Burden in the Quadriceps, Articular Cartilage and Periarticular Bone Accompanies Atrophy and Osteoarthritis Following ACL Injury in Mice
2022 · Cory M. Dungan, Nicholas T. Thomas, et al. · The FASEB Journal
Muscle fibrosis and maladaptation occur progressively in CKD and are rescued by dialysis
2021 · Camille R. Brightwell, Ameya S. Kulkarni, et al. · JCI Insight · 36
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