Genetic and estrogen-dependent regulation of the human PAC1R receptor and PTSD
Description: There is a significant need for a more mechanistic understanding of the neural circuitry of fear and its inhibition. We have recently utilized convergent genetic approaches to identify the PACAP/PAC1 receptor pathway as being associated with PTSD and with dysregulation of conditioned fear in humans. We will extend these data by examining the mechanisms by which estrogen, epigenetic modulation, and genetic polymorphisms differentially modulate PAC1 gene expression in humans.
Funding type: research
Funder scheme: R01
Start date: 2012-03-01
End date: 2017-02-28
Investigator: KERRY J. RESSLER
Institution: MCLEAN HOSPITAL
Funded outputs count: 123
Funder award ID: R01MH096764
OpenAlex ID: G4968477739