ISGylation regulates lung endothelial inflammation
Description: Lung microvascular endothelial dysfunction is a hallmark of acute lung injury and sepsis. The proposed studies will be the first to elucidate a new post-translational modification of NF-ĸBp65, ISGylation, and its inhibitory role in of NF-ĸB activation and lung endothelial inflammation. These studies will be critical in development of novel therapeutics by stabilization of ISG15 E3 ligase to diminish lung microvascular endothelial dysfunction in acute lung injury and sepsis.
Funding type: research
Funder scheme: R01
Start date: 2021-04-20
End date: 2026-03-31
Investigator: YUTONG ZHAO
Institution: OHIO STATE UNIVERSITY
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 24
Funder award ID: R01HL157164
OpenAlex ID: G71450918