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Harnessing Platelet-Endothelial Interactions for Exosome Delivery

Description: PROJECT NARRATIVE Exosome therapy is a promising strategy to tissue regeneration. However, suboptimal exosome homing to the injured tissue hampers the efficiency and outcome of exosome therapy. In the proposed study, we employ platelet and vascular biology to achieve targeted delivery of therapeutic exosomes in the injured heart tissue.
Funding type: research
Funder scheme: R01
Start date: 2019-04-01
End date: 2027-07-31
Investigator: KE CHENG
Institution: COLUMBIA UNIV NEW YORK MORNINGSIDE
Funded outputs count: 68
Funder award ID: R01HL144002
OpenAlex ID: G9000856567
2026 · Jiaming Liu, Shiqi Hu, et al. · Science Advances
2026 · Jiaming Liu, Na Yan, et al. · Bioactive Materials · 1
2026 · Yuan Li, Philippe Menasché, et al. · Acta Biomaterialia · 3
2025 · Chunxi Wang, Xiao Cheng, et al. · Molecular Therapy · 1
2025 · Yang You, Mengrui Liu, et al. · Advanced Materials · 26
2025 · Vanessa YiRan Li, Nicole Rosas, et al. · Extracellular Vesicle · 12
2025 · Xuan Mei, Dashuai Zhu, et al. · Bioactive Materials · 11
2025 · Shuo Liu, Kristen D. Popowski, et al. · Advanced Science · 7
2025 · Mengrui Liu, Brian Henick, et al. · Clinical and Translational Medicine · 2
2024 · Yilan Hu, Weihang Zhang, et al. · Journal of Molecular and Cellular Cardiology · 21
2024 · Di Carlo, Dino, Ko, Jina, et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
2024 · Junlang Li, Shenghuan Sun, et al. · Circulation · 127
2024 · Doyeon Koo, Xiao Cheng, et al. · Nature Communications · 40
2024 · Xiao Cheng, Brian S. Henick, et al. · ACS Nano · 49
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