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The LIFE Study

Description: Public Health Relevance: Should LIFE-M be successful, it would modify the current guidelines by providing a new indication for the physical activity intervention used in LIFE: the prevention or delay of major mobility disability. These results will have crucial implications for public health prevention in a rapidly aging society, and will fill an important gap in knowledge for practicing evidence-based geriatric medicine. The study will also yield valuable information concerning the efficacy and effectiveness of physical activity on a broad spectrum of other important health outcome, and will impact both clinical practice and public health policy, and will, therefore, benefit individuals and society.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2003-09-30
End date: 2018-11-30
Investigator: MARCO PAHOR
Institution: UNIVERSITY OF FLORIDA
Subfield: Physiology
Field: Medicine
Funded outputs count: 168
Funder award ID: U01AG022376
OpenAlex ID: G1276014447
Effects of physical activity on performance measures in older adult cancer survivors
2025 · Justin C. Brown, Abigail L. Tice, et al. · Cancer · 1
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Physical activity and mobility disability in older adult cancer survivors
2025 · Justin C Brown, Shengping Yang · JNCI Cancer Spectrum · 3
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Arm Based on LEg blood pressures (ABLE-BP): can systolic ankle blood pressure measurements predict systolic arm blood pressure? An individual participant data meta-analysis from the INTERPRESS-IPD Collaboration
2025 · Sinead T J McDonagh, Fiona C Warren, et al. · BMJ Open · 2
Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study
2025 · Michelle M. Mielke, Roger A. Fielding, et al. · The journal of nutrition health & aging · 12
Effects of a Physical Activity Intervention on Perceived Stress, Fatigue, and Depressive Symptoms in Older Adults: A Secondary Analysis of the LIFE Study
2024 · Emily J Smail, Christopher N Kaufmann, et al. · The Journals of Gerontology Series A · 7
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Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial
2023 · Anoop Sheshadri, Mason Lai, et al. · Kidney Medicine · 5
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Older adults with clinically relevant depressive symptoms have equal mobility benefit from a chronic physical activity intervention
2023 · Emily J. Smail, Christopher N. Kaufmann, et al. · Mental health and physical activity · 2
Physical activity, interleukin-6 change, and gait speed
2023 · Francesco Panza, Carlo Custodero, et al. · Aging · 4
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Effect of Physical Activity Intervention on Gait Speed by Frailty Condition: A Randomized Clinical Trial
2023 · Carlo Custodero, Pasquale Agosti, et al. · Journal of the American Medical Directors Association · 21
Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis
2022 · Amanda E. Paluch, Shivangi Bajpai, et al. · Circulation · 117
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Effect of change of interleukin-6 over time on gait speed response: Results from the lifestyle interventions and independence for elders study
2022 · Carlo Custodero, Marco Pahor, et al. · Mechanisms of Ageing and Development · 6
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Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
2022 · Roger A. Fielding, Elizabeth J. Atkinson, et al. · GeroScience · 75
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Gradient and Acceleration of Decline in Physical and Cognitive Functions in Older Adults: A Disparity Analysis
2022 · Edward H Ip, Shyh-Huei Chen, et al. · The Journals of Gerontology Series A · 2
Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults
2022 · Michael G. Shlipak, Anoop Sheshadri, et al. · JAMA Internal Medicine · 66
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Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial
2021 · Anda Botoseneanu, Haiying Chen, et al. · Experimental Gerontology · 8
Elevated IL-6 and CRP Levels Are Associated With Incident Self-Reported Major Mobility Disability: A Pooled Analysis of Older Adults With Slow Gait Speed
2021 · Daniel P Beavers, Stephen B Kritchevsky, et al. · The Journals of Gerontology Series A · 23
Ratings of Perceived Exertion During Walking: Predicting Major Mobility Disability and Effect of Structured Physical Activity in Mobility-Limited Older Adults
2021 · Erta Cenko, Haiying Chen, et al. · The Journals of Gerontology Series A · 3
Conversion between the Modified Mini‐Mental State Examination (3MSE) and the Mini‐Mental State Examination (MMSE)
2021 · Edward H. Ip, June Pierce, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 13
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Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study
2020 · Joshua D. Brown, Golnoosh Alipour-Haris, et al. · Journal of Clinical Medicine · 21
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Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study
2020 · Patrick Squires, Marco Pahor, et al. · Journal of Clinical Medicine · 17
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Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study
2020 · Joshua D. Brown, Wei-Hsuan Lo-Ciganic, et al. · Journal of Clinical Medicine · 20
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Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older Adults
2020 · Jaime Lynn Speiser, Kathryn E Callahan, et al. · The Journals of Gerontology Series A · 68
Relationships Between Profiles of Physical Activity and Major Mobility Disability in the LIFE Study
2020 · Jason Fanning, W. Jack Rejeski, et al. · Journal of the American Geriatrics Society · 23
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability
2020 · Marco Pahor, Jack M. Guralnik, et al. · Journal of the American Geriatrics Society · 42
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Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability
2019 · Nancy W. Glynn, Theresa Gmelin, et al. · Journal of the American Geriatrics Society · 8
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