Causes of Immune Cell Senescence in Aging Humans
Description: The goal of this study is to identify peripheral blood mononuclear cell (PBMC) populations that increasingly undergo cellular senescence with advancing age in the human population, to characterize senescence of human PBMC subsets on the genomic level, and test strategies to suppress senescence of human circulating immune cells. Therapeutic interventions to suppress senescence of PBMC subsets has the potential to improve healthspan and suppressing age-associated diseases including pulmonary fibrosis, obesity, type 2 diabetes, sarcopenia, osteoarthritis, atherosclerosis, tau-dependent neurodegenerative diseases, including Alzheimer's disease, among others.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R21
Start date: 2020-05-15
End date: 2024-04-30
Investigator: PATRICIA FITZGERALD-BOCARSLY
Institution: RBHS-NEW JERSEY MEDICAL SCHOOL
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 7
Funder award ID: R21AG067368
OpenAlex ID: G5341850658