The role of mTOR inhibition on longevity and healthy aging in a non-human primate
Description: PUBLIC HEALTH RELEVANCE: Inhibition of the mTOR signaling pathway has been shown to extend both lifespan and healthspan in mice, but the implications of these findings for improving normal, healthy aging in humans is largely unknown. To bridge this knowledge gap, we propose testing whether mTOR inhibition through chronic administration of rapamycin delays aging in a non-human primate, the common marmoset, as an important step towards translational approaches to delay age-related disease in humans.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2015-09-30
End date: 2022-05-31
Investigator: ADAM SALMON
Institution: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Subfield: Aging
Domain: Life Sciences
Funded outputs count: 41
Funder award ID: R01AG050797
OpenAlex ID: G1378535233