Pathogenesis and in Vivo Suppression of Thin Filament-based Cardiomyopathies
Description: Project Narrative We propose to use transgenic Drosophila melanogaster (fruit flies) and mice, to define the mechanisms by which post-translational modifications to actin modulate thin filament and cardiac contractile regulation. We will also scrutinize new fly models of actin and troponin-T-based cardiomyopathies to determine the molecular defects that drive distinct forms of adverse myocardial remodeling. Finally, we will ascertain if specific actin post- translational modifications improve or exacerbate heart muscle diseases caused by an array of mutations in the contractile machinery.
Funding type: research
Funder scheme: R01
Start date: 2015-09-01
End date: 2026-12-31
Investigator: ANTHONY CAMMARATO
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 39
Funder award ID: R01HL124091
OpenAlex ID: G9000917352