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Regulation of mitochondrial respiratory complex I dynamics

Description: PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because the studies on respiratory Complex I assembly will shed light on the pathogenesis of many human disorders with Complex I dysfunction. It would also identify new candidate genes for neurological diseases and provide new treatment targets for mitochondrial diseases.
Funding type: research
Funder scheme: R01
Start date: 2014-08-01
End date: 2020-05-31
Investigator: YIDONG BAI
Institution: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Funded outputs count: 19
Funder award ID: R01GM109434
OpenAlex ID: G1758854849
Characterizing the Electron Transport Chain: Structural Approach
2022 · Ting Liang, Janice Deng, et al. · Methods in molecular biology · 5
Characterizing the Electron Transport Chain: Functional Approach Using Extracellular Flux Analyzer on Mouse Tissue Samples
2022 · Ting Liang, Jay Dunn, et al. · Methods in molecular biology · 4
Mitochondrial chaperones in human health and disease
2021 · Tyler Bahr, Joshua Katuri, et al. · Free Radical Biology and Medicine · 43
Creating Cell Model 2.0 Using Patient Samples Carrying a Pathogenic Mitochondrial DNA Mutation: iPSC Approach for LHON
2021 · Pragya Singh, Tyler Bahr, et al. · Methods in molecular biology · 6
Mitophagy activation repairs Leber’s hereditary optic neuropathy-associated mitochondrial dysfunction and improves cell survival
2018 · Lokendra Kumar Sharma, Meenakshi Tiwari, et al. · Human Molecular Genetics · 44
The interaction between mitochondria and oncoviruses
2017 · Shujie Song, Shasha Gong, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 17
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Aging-associated mitochondrial DNA mutations alter oxidative phosphorylation machinery and cause mitochondrial dysfunctions
2017 · Hongzhi Li, Luxi Shen, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 43
Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance
2017 · Hongzhi Chen, Juli Bai, et al. · The FASEB Journal · 27
Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation
2016 · Julie C. Etzler, Mariana Bollo, et al. · Archives of Biochemistry and Biophysics · 22
Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation
2016 · Pingping Jiang, Min Liang, et al. · Human Molecular Genetics · 46
Mitochondrial metabolites extend lifespan
2016 · Robert J. Mishur, Maruf Khan, et al. · Aging Cell · 50
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Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress
2015 · Hezhongrong Nie, Guorong Chen, et al. · Mitochondrion · 30
Exercise intolerance and developmental delay associated with a novel mitochondrial ND5 mutation
2015 · Hezhi Fang, Hao Shi, et al. · Scientific Reports · 23
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Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly
2015 · Rasika Vartak, Janice Deng, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 25
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Respiratory supercomplexes plasticity and implications
2015 · Yidong Bai · Frontiers in bioscience · 39
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An update on complex I assembly: the assembly of players
2014 · Rasika S. Vartak, Manpreet Kaur Semwal, et al. · Journal of Bioenergetics and Biomembranes · 31
A nonapoptotic role for CASP2/caspase 2
2014 · Meenakshi Tiwari, Lokendra K Sharma, et al. · Autophagy · 75
Respiratory supercomplexes: structure, function and assembly
2013 · Rasika Vartak, Christina Ann-Marie Porras, et al. · Protein & Cell · 105
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Comparative bioenergetic study of neuronal and muscle mitochondria during aging
2013 · Hongzhi Li, Lokendra Kumar Sharma, et al. · Free Radical Biology and Medicine · 22
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