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Does Lifestyle Intervention in Obese Older Adults Improve Bone Quality?

Description: PROJECT NARRATIVE Obesity is an increasingly prevalent health problem in older adults that affects ability to maintain independent living and satisfaction of life. Although changing life-long unhealthy habits can be successful at reducing obesity, weight loss is not universally prescribed to older persons because of concern about potential harmful effects on bone health. This study will investigate whether lifestyle change resulting in weight loss will preserve or improve the strength of bone and thus, reduce fracture risks in obese, older men and women.
Funding type: research
Funder scheme: R01
Start date: 2017-06-01
End date: 2025-05-31
Investigator: DENNIS T. VILLAREAL
Institution: BAYLOR COLLEGE OF MEDICINE
Field: Medicine
Funded outputs count: 17
Funder award ID: R01DK109950
OpenAlex ID: G729920252
Bone quality response to lifestyle intervention in older adults with obesity (LIMB-Q trial): a randomised controlled trial
2025 · Giulia Gregori, Sanjay Mediwala, et al. · The Lancet Healthy Longevity · 7
The Benefits of Exercise Training in Combination With Weight Loss Therapies
2025 · Bryan C. Jiang, Dennis T. Villareal · Diabetes · 9
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High-Fidelity Finite Element Modeling Technique to Improve Sensitivity to Bone Tissue Changes of Older Adults with Obesity undergoing Intensive Lifestyle Intervention
2025 · Michael A. K. Liebschner, Daeseung Kim, et al. · Annals of Biomedical Engineering · 2
What weight changes really happened during COVID-19 among older adults?
2024 · John A. Batsis, Dennis T. Villareal · The journal of nutrition health & aging
Should the Incretin hype be the same for older adults: Promise + cautions
2024 · John A. Batsis, Kathryn N. Porter Starr, et al. · Journal of the American Geriatrics Society · 8
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Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity
2023 · Henry D. Heisey, Clifford Qualls, et al. · Journal of Geriatric Psychiatry and Neurology · 1
Indices of sarcopenic obesity are important predictors of finite element analysis-derived bone strength in older adults with obesity
2023 · Giulia Gregori, Arjun Paudyal, et al. · Frontiers in Endocrinology · 11
Life’s Essential 8
2023 · Manish Kumar, Ariela Orkaby, et al. · JACC Advances · 39
Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating
2023 · Satchidananda Panda, Geraldine Maier, et al. · The Journals of Gerontology Series A · 23
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Obesity and Accelerated Aging
2023 · Dennis T. Villareal · The journal of nutrition health & aging · 37
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Weight strategy in older adults with obesity: calorie restriction or not?
2022 · Georgia Colleluori, Dennis T. Villareal · Current Opinion in Clinical Nutrition & Metabolic Care · 12
Truncal Fat and Frailty Are Important Predictors of Cognitive Performance among Aging Adults with Obesity
2022 · H.D. Heisey, M.E. Kunik, et al. · The journal of nutrition health & aging · 5
Aging, obesity, sarcopenia and the effect of diet and exercise intervention
2021 · Georgia Colleluori, Dennis T. Villareal · Experimental Gerontology · 201
Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss
2019 · Georgia Colleluori, Lina Aguirre, et al. · Cell Metabolism · 135
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Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity
2019 · Bryan C. Jiang, Dennis T. Villareal · Journal of Nutrition in Gerontology and Geriatrics · 50
Therapeutic and lifestyle approaches to obesity in older persons
2018 · Bryan C. Jiang, Dennis T. Villareal · Current Opinion in Clinical Nutrition & Metabolic Care · 18
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
2018 · John A. Batsis, Dennis T. Villareal · Nature Reviews Endocrinology · 1,379
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