Multivariate Modeling of the Neural Mechanisms of Treatment Response in Opioid Addiction
Description: PROJECT NARRATIVE The proposed K01 project will use multimodal magnetic resonance imaging and machine learning techniques to elucidate the structural and functional brain mechanisms underlying treatment failure in young adults receiving treatment with injectable extended-release naltrexone (XR-NTX) for opioid use disorder. This project will unveil the neural mechanisms underlying individual variability in XR-NTX treatment response in a population of high importance to the efforts to curb the opioid crisis. It will facilitate Dr. Zhenhao Shi's transition to an independent computational addiction neuroscientist and help inform future research of, and intervention strategies for, opioid addiction.
Funder: National Institute on Drug Abuse
Funding type: career_development
Funder scheme: K01
Start date: 2021-04-15
End date: 2026-03-31
Investigator: ZHENHAO SHI
Institution: UNIVERSITY OF PENNSYLVANIA
Funded outputs count: 29
Funder award ID: K01DA051709
OpenAlex ID: G9000902510