Mechanisms of Manganese Neurotoxicity
Description: Environmental exposure to excessive manganese impairs basal ganglia function, resulting in a neurological disorder relatively similar to Parkinsonism commonly known as Manganism. Manganese exposure is of serious concern due to the increased incidences of extrapyramidal neurological symptoms among miners and industrial workers, including welders. Manganese predominantly accumulates in the basal ganglia structures and causes mitochondrial dysfunction, oxidative stress, and apoptosis. However, cellular and molecular mechanisms underlying manganese neurotoxicity are poorly understood. The proposed study will elucidate the neurotoxic mechanisms underlying manganese induced upregulation of a proapoptotic kinase PKCd and its functional relevance to manganese neurotoxicity.
Funding type: research
Funder scheme: R01
Start date: 2000-08-05
End date: 2017-03-31
Investigator: ANUMANTHA GOUNDER KANTHASAMY
Institution: IOWA STATE UNIVERSITY
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Funded outputs count: 85
Funder award ID: R01ES010586
OpenAlex ID: G4652158022