Effects of GLP-l receptor agonists on cardiometabolic alterations in HIV-associated lipohypertrophy
Description: PROJECT NARRATIVE Despite the advent of safer HIV therapies, accumulation of central fat and ectopic fat (in the liver and around the heart) remains a common and significant challenge facing HIV providers and threatens the well-being of individuals living with HIV. In this study, we will comprehensively study the effects of a promising class of drugs never before studied in HIV, glucagon-like peptide-1 receptor agonists, on alleviating fat abnormalities, insulin resistance, inflammation, and cardiovascular risk in HIV. The results of this study should inform public health efforts to ameliorate the risk of metabolic abnormalities and cardiovascular disease not only in people living with HIV, but also in other conditions where inflammation is enhanced, such as rheumatoid arthritis.
Funding type: research
Funder scheme: R01
Start date: 2019-04-10
End date: 2025-03-31
Investigator: ALLISON ROSS ECKARD
Institution: CASE WESTERN RESERVE UNIVERSITY
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 14
Funder award ID: R01DK121619
OpenAlex ID: G2186341741