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Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease risk

Funding type: research
Funder scheme: R01
Start date: 2007-06-01
End date: 2012-05-31
Investigator: CHANDRA A REYNOLDS
Institution: UNIVERSITY OF CALIFORNIA RIVERSIDE
Funded outputs count: 71
Funder award ID: R01AG028555
OpenAlex ID: G4075787065
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
2025 · Elham Assary, Jonathan R. I. Coleman, et al. · Nature Human Behaviour · 9
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Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up
2025 · Weiyao Yin, Xia Li, et al. · Biogerontology · 2
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Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
2023 · Jonathan K L Mak, Ida K Karlsson, et al. · The Journals of Gerontology Series A · 33
Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings
2023 · Christopher E McMurran, Yunzhang Wang, et al. · Brain · 22
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Handedness in twins reared apart: A review of the literature and new data
2023 · Gareth Richards, Nancy L. Segal · Neuropsychologia · 3
Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study
2023 · Elsa Ojalehto, Yiqiang Zhan, et al. · EClinicalMedicine · 20
Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels
2022 · Ida K. Karlsson, Yiqiang Zhan, et al. · European Journal of Epidemiology · 23
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A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
2022 · Albert T. Higgins-Chen, Kyra L. Thrush, et al. · Nature Aging · 498
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Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer’s Disease in Nordic Populations
2022 · Ehsan Motazedi, Weiqiu Cheng, et al. · Journal of Alzheimer s Disease · 12
Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality: a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years
2022 · Peggy Ler, Xia Li, et al. · BMC Public Health · 7
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Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells
2022 · Ida K Karlsson, Alexander Ploner, et al. · Research Square
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Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins
2021 · Ida K. Karlsson, Valentina Escott-Price, et al. · Brain Communications · 93
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Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
2021 · Alexandra M. Wennberg, Weiyao Yin, et al. · Scandinavian Journal of Public Health · 6
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease
2021 · Douglas P. Wightman, Iris E. Jansen, et al. · Nature Genetics · 1,011
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A genome‐wide association study of the frailty index highlights brain pathways in ageing
2021 · Janice L Atkins, Juulia Jylhävä, et al. · Aging Cell · 320
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Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?
2021 · Ge Bai, Agnieszka Szwajda, et al. · Age and Ageing · 44
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Epigenome-wide association study of level and change in cognitive abilities from midlife through late life
2021 · Ida K. Karlsson, Malin Ericsson, et al. · Clinical Epigenetics · 3
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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
2021 · Jenny van Dongen, Fiona A. Hagenbeek, et al. · Molecular Psychiatry · 39
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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
2021 · Vasiliki Lagou, Reedik Mägi, et al. · Nature Communications · 163
Largest GWAS (N=1,126,563) of Alzheimer’s Disease Implicates Microglia and Immune Cells
2020 · Douglas P Wightman, Iris E Jansen, et al. · medRxiv · 42
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A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation
2020 · Chandra A. Reynolds, Qihua Tan, et al. · Aging Cell · 64
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Age-dependent effects of body mass index across the adult life span on the risk of dementia: a cohort study with a genetic approach
2020 · Ida K. Karlsson, Kelli Lehto, et al. · BMC Medicine · 43
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A Twin Study of Sex Differences in Genetic Risk for All Dementia, Alzheimer’s Disease (AD), and Non-AD Dementia
2020 · Christopher R. Beam, Cody Kaneshiro, et al. · Journal of Alzheimer s Disease · 17
Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden
2020 · Emma Raymond, Chandra A Reynolds, et al. · The Journals of Gerontology Series A · 41
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Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
2020 · Xia Li, Alexander Ploner, et al. · eLife · 390
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