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TREAT (Time Restricted EATing) to improve cardiometabolic health

Description: Project Narrative Over half of American adults have overweight or obesity and are at high risk of developing type 2 diabetes and cardiovascular diseases. Although caloric restriction has many health benefits, it is difficult to sustain overtime for most people. Time restricted eating (TRE), a novel type of intermittent fasting, facilitates adherence to the intervention and results in weight loss and improvement of metabolism. We propose to test the effect of an intervention aiming to restrict the eating window to 10 hours/day, compared to habitual prolonged eating duration of >14hours/day, delivered via a smartphone application, on weight loss and metabolism, in metabolically unhealthy adults aged 50 to 70 y old, with overweight or obesity. We hypothesize that TRE, compared to habitual long duration of eating, will decrease cardiovascular risk burden.
Funding type: research
Funder scheme: R01
Start date: 2020-09-30
End date: 2026-06-30
Investigator: BLANDINE B LAFERRERE
Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES
Subfield: Physiology
Field: Medicine
Funded outputs count: 20
Funder award ID: R01AG065569
OpenAlex ID: G1188367645
2026 · Leinys S. Santos-Báez, Omer Kazmi, et al. · INQUIRY The Journal of Health Care Organization Provision and Financing
2025 · Leinys S. Santos‐Báez, Blandine Laferrère · Obesity
2025 · Leinys S. Santos‐Báez, Diana A. Diaz‐Rizzolo, et al. · Diabetes Obesity and Metabolism · 9
2024 · Collin J. Popp, Emily N. C. Manoogian, et al. · JAMA Network Open · 1
2023 · Emily N. C. Manoogian, Blandine Laferrère · Obesity · 21
2022 · Leinys S. Santos–Báez, Alison Garbarini, et al. · Contemporary Clinical Trials · 12
2022 · Blandine Laferrère, Satchidananda Panda · New England Journal of Medicine · 14
2022 · Emily N. C. Manoogian, Julie Wei-Shatzel, et al. · International Journal of Obesity · 34
2021 · Collin J. Popp, Margaret Curran, et al. · Nutrients · 37
2021 · Emily N C Manoogian, Lisa S Chow, et al. · Endocrine Reviews · 346
2021 · Ainslee Crose, Alison Alvear, et al. · Nutrients · 35
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