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The Impact of Traumatic Stress on the Methylome: implications for PTSD

Description: Narrative Multiple studies report DNA methylation differences that distinguish PTSD cases from symptom-free controls after exposure to a traumatic event. The purpose of this study is to identify replicable patterns of DNA methylation that associate with PTSD, characterize cross-tissue similarities between blood and brain, and determine the degree to which these patterns change in response to effective PTSD treatment.
Funding type: research
Funder scheme: R01
Start date: 2016-08-18
End date: 2026-05-31
Investigator: MARK W LOGUE
Institution: EMORY UNIVERSITY
Funded outputs count: 37
Funder award ID: R01MH108826
OpenAlex ID: G7230273445
2025 · Kira D. Höffler, Seyma Katrinli, et al. · Epigenetics & Chromatin · 4
2025 · Alicia K. Smith, Seyma Katrinli, et al. · Brain Behavior and Immunity · 11
2025 · Xiang Zhao, Seyma Katrinli, et al. · Psychological Medicine · 8
2024 · Aziz Elbasheir, Seyma Katrinli, et al. · JAMA Network Open · 36
2024 · Shota Nishitani, Alicia K Smith, et al. · Epigenomics · 2
2022 · Kenneth M. McCullough, Seyma Katrinli, et al. · Translational Psychiatry · 14
2022 · Seyma Katrinli, Nayara C. S. Oliveira, et al. · Translational Psychiatry · 178
2021 · Seyma Katrinli, Alicia K. Smith · Neurobiology of Stress · 26
2020 · Alicia K. Smith, Andrew Ratanatharathorn, et al. · Nature Communications · 133
2020 · Seyma Katrinli, Yuanchao Zheng, et al. · Brain Behavior and Immunity · 37
2020 · Seyma Katrinli, Jennifer Stevens, et al. · Neuropsychopharmacology · 95
2020 · Agaz H Wani, D Armstrong, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
2020 · the Traumatic Stress Brain Study Group, Mark W. Logue, et al. · Clinical Epigenetics · 102
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