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Primary fibroblast resiliency as a predictor of health and lifespan in mice

Description: The goal of this proposal is to standardize tests of cellular resiliency using a skin-derived fibroblast model as a means to delineate the relationship between resiliency and mechanisms that regulate the aging process. We describe in depth a set of fibroblast resiliency assessments that we believe are representative of physiological cellular responses associated with longevity and test their correlation to natural mouse longevity and their ability to determine the potential of interventions to alter longevity. Because we currently lack standardized research tools to probe resiliency, this marker of resilience has the potential to be a highly important marker of healthspan and longevity in mouse studies.
Funding type: research
Funder scheme: R01
Start date: 2017-09-15
End date: 2024-05-31
Investigator: ADAM SALMON
Institution: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Subfield: Aging
Funded outputs count: 24
Funder award ID: R01AG057431
OpenAlex ID: G140508435
Tissue-specific molecular regulation of aging mechanisms with methionine restriction in mice and the potential role of methionine sulfoxide reductase
2025 · Kevin M Thyne, Raechel Camones, et al. · The Journals of Gerontology Series A · 2
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
2024 · Daniel A. Adekunbi, Hillary F. Huber, et al. · Neurobiology of Aging · 2
Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring
2024 · Daniel A. Adekunbi, Bowen Yang, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Differential mitochondrial bioenergetics and cellular resilience in astrocytes, hepatocytes, and fibroblasts from aging baboons
2024 · Daniel A. Adekunbi, Hillary F. Huber, et al. · GeroScience · 7
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Sulfur Amino Acid Restriction alters mitochondrial function depending on tissue, sex, and Methionine sulfoxide reductase A (MsrA) status.
2023 · Kevin M. Thyne, Raechel Camones, et al. · Research Square · 1
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Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction
2023 · Kevin M. Thyne, Adam B. Salmon · GeroScience · 9
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Testing the evidence that lifespan-extending compound interventions are conserved across laboratory animal model species
2023 · Michael Bene, Adam B. Salmon · GeroScience · 13
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Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging
2022 · Milos Marinkovic, Qiuxia Dai, et al. · Matrix Biology · 30
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Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice
2022 · Zhou Jiang, Juan Wang, et al. · Scientific Reports · 21
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Metabolic benefits of methionine restriction in adult mice do not require functional methionine sulfoxide reductase A (MsrA)
2022 · Kevin M. Thyne, Adam B. Salmon · Scientific Reports · 14
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Resilience to aging is a heterogeneous characteristic defined by physical stressors
2022 · Haoyi Lei, Derek M. Huffman, et al. · Aging Pathobiology and Therapeutics · 12
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Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells
2021 · Daniel A. Adekunbi, Cun Li, et al. · GeroScience · 5
Beta-guanidinopropionic acid does not extend Drosophila lifespan
2021 · Jonathan D. Dorigatti, Kevin M. Thyne, et al. · Biochemistry and Biophysics Reports · 1
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
2021 · Jonathan D. Dorigatti, Kevin M. Thyne, et al. · GeroScience · 11
Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging
2020 · Angela O. Dorigatti, Stacy A. Hussong, et al. · GeroScience · 2
Mitochondrial-targeted methionine sulfoxide reductase overexpression increases the production of oxidative stress in mitochondria from skeletal muscle.
2020 · Arunabh Bhattacharya, Daniel Pulliam, et al. · Aging Pathobiology and Therapeutics · 2
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TORwards a Victory Over Aging
2019 · Dudley W Lamming, Adam B Salmon · The Journals of Gerontology Series A · 6
Is Rapamycin a Dietary Restriction Mimetic?
2019 · Archana Unnikrishnan, Kavitha Kurup, et al. · The Journals of Gerontology Series A · 39
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Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset
2019 · Elizabeth Fernandez, Corinna Ross, et al. · Pathobiology of Aging & Age-related Diseases · 18
Long‐term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets
2018 · Aubrey M. Sills, Joselyn M. Artavia, et al. · American Journal of Primatology · 16
Aging research using the common marmoset: Focus on aging interventions
2018 · Corinna N. Ross, Adam B. Salmon · Nutrition and Healthy Aging · 35
Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions
2018 · Adam B. Salmon, Jonathan Dorigatti, et al. · GeroScience · 16
Hydrogen sulfide ameliorates aging-associated changes in the kidney
2018 · Hak Joo Lee, Denis Feliers, et al. · GeroScience · 69
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Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice
2018 · Roxanne Weiss, Elizabeth Fernandez, et al. · Aging · 36
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